Even for exempt media, the laboratory cannot simply place the items on the shelf. The user must verify and document the following upon receipt:
: Media types that have a historically low failure rate when prepared by a reputable commercial manufacturer. Laboratories are not required to perform full maintenance QC (such as sterility and performance testing) on these media batches, provided the manufacturer supplies documentation of compliance.
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It identifies specific media that have historically low failure rates (exempt), allowing labs to reduce the intensity of their internal QC testing.
The third edition introduced several important revisions and clarifications over its predecessor: Even for exempt media, the laboratory cannot simply
Media with historically low failure rates (e.g., Sheep Blood Agar, MacConkey Agar, Chocolate Agar from certified sources). Laboratories do not need to perform organism challenges on these, provided the manufacturer supplies a QC certificate.
The CLSI M22-A3 standard remains a cornerstone of laboratory quality management. By streamlining QC for reliable commercial products, it allows laboratories to focus resources on more complex testing while maintaining a high safety standard for patient care. : You can purchase and download the full
To obtain a legitimate, safe, and up-to-date PDF link for CLSI M22-A3, you must use official channels:
: The official M22 product page allows you to purchase the PDF or a print version.